Basal Ganglia Involvement in Neuro-AIDS

Arendt, G., Hefter, H., Büscher, L., Elsing, C., Freund, H.-J. 1992. Improvement of motor performance of HIv-positive patients under AZT-therapy. Neurology 42, 891-898

Basal ganglia are located deeply within both cerebral hemispheres. Their task is to control muscle movement. Basal ganglia are affected early during the course of Neuro-AIDS. With the help of special basal ganglia tests we are able to detect the earliest signs of basal ganglia dysfunction. Such tests are helpful for an early diagnosis of brain involvement in AIDS. Since 1982, HIV is known to be neurotropic with patients having motor, cognitive and emotional deficits characterising the so-called HIV-1-associated encephalopathy.

The ConTreMRAM System

The ConTreMRAM system allows the user to easily perform the three required tests on voluntary index finger contraction, tremor, and most rapid alternating movements. The graphical user interface is easy to “read” and intuitively and semi-automatically guides the experimenter through the test procedure. Quality control and final data evaluation are performed automatically. Results are presented in standard text- or MS-Excel-files.

The  setup for the index finger contraction experiment is depicted below (left). The reaction and contraction times are automatically extracted from each repetition and enter the statistical evaluation.

Last modified 05/18/07 11:48                       Upward